Neurostimulation for Epilepsy

“Neurostimulation for Epilepsy is a comprehensive and authoritative book previously unavailable in this emerging treatment field that provides a detailed exploration of the principles, device technology, and applications of neurostimulation for epilepsy. With contributions from a team of expert researchers and clinicians, the book covers various neurostimulation techniques, including vagus nerve stimulation, deep brain stimulation, responsive neurostimulation, and non-invasive brain stimulation. The book provides insights into the latest advancements in next-generation brain sensing and stimulation devices, as well as their impact on neurocognitive outcomes and quality of life. This work is an invaluable resource for researchers, clinicians, and anyone seeking a deeper understanding of the role of neurostimulation in managing epilepsy.” – Kate Davis, MD, MS, FAES, FANA, Associate Professor of Neurology, Director, Penn Epilepsy Center”Dr. Rao has assembled an impressive group of world-renowned experts in this effort. The book covers all aspects of neurostimulation for epilepsy, from basic principles to clinical trial results to practical advice to possible future applications. In addition to thorough discussions of the “big three” (VNS, DBS and RNS), the book also covers epicranial stimulation and emerging methods of noninvasive stimulation including transcranial magnetic stimulation and low intensity focused ultrasound. There are chapters on applications of the long-term data obtained from these systems, and the effects of neurostimulation on quality of life, cognition and mood. The chapters are well written, thorough yet concise, and very well referenced. There is something for everyone in this book, from those just starting to learn about neurostimulation to experts using it regularly. This is a welcome addition to the library for anyone involved in treating refractory epilepsy or performing related research.” –Lawrence J. Hirsch, MD, Professor of Neurology, Chief, Division of Epilepsy and EEG, Co-Director, Comprehensive Epilepsy Center, Yale University School of Medicine”I highly recommend “Neurostimulation for Epilepsy.” It is a comprehensive guide and offers valuable insights. The book covers the essential topics in the various neuromodulation therapies used in epilepsy. This manual provides a balance blend of clinical expertise and educational content, making it an excellent resource for experienced practitioners, researchers as well as those in the early stages of their career.” –Dileep Nair, MD, Professor of Neurology, CCLCM/CWRU; Head of Section of Adult Epilepsy, Neurological Institute; Cleveland Clinic“This book focuses on neurostimulation in epilepsy, covering aspects of basic science and engineering, followed by a practical review of the nuances and application of the devices currently available. The purpose of the book is to provide a contemporary review of the neurostimulation devices available for epilepsy, with attention to the known mechanisms of action, aspects of their design and engineering, practical application in the clinical realm, ways to leverage data collected by the devices to tailor stimulation parameters for optimization of treatment, and research that may advance the field… Well-designed figures and tables that help summarize important or complex concepts accompany the text. The book ends nicely with a patient-centered chapter detailing aspects of living with a neurostimulation device in terms of quality of life, cognition, and mood.” –©Doody’s Review Service, 2024, Robert McInnis, MD (Weill Cornell Medical College)

Vikram Rao, MD, PhD is a neurologist who specializes in epilepsy and is an Associate Professor of Clinical Neurology at UCSF. He is Chief of the Epilepsy Division at UCSF and also conducts research in epileptology. He takes a holistic approach to helping patients deal with the challenges of their seizures and works at multiple levels to improve their quality of life. He has a special interest in utilizing implanted neurostimulation devices to treat drug-resistant forms of epilepsy. Rao’s research involves using direct brain electrical recordings made with implanted devices to understand how abnormal patterns of brain electricity give rise to seizures.