Robinson Crusoe

Daniel Defoe relates the tale of an English sailor marooned on a desert island for nearly three decades. An ordinary man struggling to survive in extraordinary circumstances, Robinson Crusoe wrestles with fate and the nature of God. This edition features maps.

“"Beyond the end ofRobinson Crusoeis a new world of fiction. Even though it did not know itself to be a 'novel,' and even though there were books that we might now call 'novels' published before it,Robinson Crusoehas made itself into a prototype . . . Perhaps because of all the novels that we have read . . . the novelty of Defoe's fiction is the more striking when we return to it. Here it is, at the beginning of things, with its final word reaching out into the future." from the Introduction by John Mullan From the Hardcover edition.”

“Beyond the end of Robinson Crusoe is a new world of fiction. Even though it did not know itself to be a ‘novel,’ and even though there were books that we might now call ‘novels’ published before it, Robinson Crusoe has made itself into a prototype . . . Perhaps because of all the novels that we have read . . . the novelty of Defoe’s fiction is the more striking when we return to it. Here it is, at the beginning of things, with its final word reaching out into the future.” –from the Introduction by John Mullan

Daniel Defoe was born Daniel Foe in London in 1660. It was perhaps, ineveitable that Defoe, an outspoken man, would become a political journalist. As a Puritan he believed God had given him a mission to print the truth, that is, to proselytize on religion and politics, and in fact, he became a prolific pamphleteer satirizing the hypocrisies of both Church and State. Defoe admired William III, and his poem The True-Born Englishman (1701) won him the King's friendship. But an ill-timed satire on High Church extremists, The Shortest Way with the Dissenters, published during Queen Anne's reign, resulted in his being pilloried and imprisoned for seditious libel in 1703.At fifty-nine Defoe turned to fiction, completing The Life and Strange Surprising Adventures of Robinson Crusoe (1719), partly based on the saga of Alexander Selkirk, a Scottish sailor; Moll Flanders (1722); Colonel Jack (1722); A Journal of the Plague Years (1722); and Roxana or the Fortunate Mistress (1724).

The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells. They are also the major histocompatibilty barriers to transplantation, which is the clinical paradigm of the self versus non self concept. It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to be important in many aspects of clinical practice. As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, and immunogenetic laboratories specializing in these methods have developed to support transplantation and other clinical programs. Immunogenetics: Methods and Applications in Clinical Practice focuses on methods for human clinical practice. The emphasis rests on those assays which are of established or potential clinical utility and are likely to be included in the repertoire of tests provided by a routine diagnostic and service laboratory. This volume also contains several review chapters of the MHC complex, the KIR complex, the human immunoglobulin allotypes, as well as reviews of the methods for the detection of alloreactive NK cells and the detection of HLA antibodies by solid phase assays.

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