1. Introduction: The importance of toxins 2. The Golden Age of microbiology 3. The search for mechanism: the study of diphtheria 4. The three ways that toxins attack cells 5. New toxins explain old diseases 6. From poison to cure 7. Deadly weapons: the abuse of biology 8. The cell biologist's 'toolkit': tools to explain us 9. Where now? Appendix I: A brief summary of molecular biology Appendix II: Some basic concepts in cell biology Further reading Index
Alistair Lax takes a fascinating look at these most devious molecules, explaining the many ingenious mechanisms they use to penetrate our cell's defences, and the deadly pandemics that result. A story not only of disease but also of human rivalry and persistence in our struggle to understand, combat, and harness these powerful toxins.
Alistair Lax takes a fascinating look at these most devious molecules, explaining the many ingenious mechanisms they use to penetrate our cell's defences, and the deadly pandemics that result. A story not only of disease but also of human rivalry and persistence in our struggle to understand, combat, and harness these powerful toxins.
What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful biological poisons released by bacteria and some plants. In Toxin, Alistair Lax reveals thepanoply of ways in which bacterial toxins overcome the defences of our cells. He explains how they work, how they are so successful in causing major diseases, the terrible human impact they have had, and howapparently 'new' diseases arise from them. He also discusses how we can combat toxins, and how we can harness their actions for beneficial purposes. Enlivened by the very human story of the persistence, rivalries, and insights from which modern microbiology grew, Toxin is the first widely accessible account of this exciting and important topic.
“An enjoyable read. I would thoroughly recommend Toxin to students of biology and related subjects.”
Susan Omar, Biologist
Alistair Lax is Professor of Cellular Microbiology at King's 3ollege London. His research has focused on the interaction of bacterial toxins with the cells in the host's body. He has published numerous papers in international journals. This is his first book for the wider public.
What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful biological poisons released by bacteria and some plants. In Toxin, Alistair Lax reveals the panoply of ways in which bacterial toxins overcome the defences of our cells. He explains how they work, how they are so successful in causing major diseases, the terrible human impact they have had, and how apparently 'new' diseases arise from them. He also discusses how we can combat toxins, and how we can harness their actions for beneficial purposes. Enlivened by the very human story of the persistence, rivalries, and insights from which modern microbiology grew, Toxin is the first widely accessible account of this exciting and important topic.
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