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Organic Synthesis

  • Hardcover
One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials.
Organic Synthesis
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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This "disconnection" approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student's experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses.
Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.
In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.
Paul Wyatt, "Senior Lecturer and Director of Undergraduate Studies, School of Chemistry," "University of Bristol, UK" and Stuart Warren, "Reader in Organic Chemistry, Department of Chemistry, University of Cambridge," "UK,"
Preface vii General References ix 1. The Disconnection Approach 1 2. Basic Principles: Synthons and Reagents: Synthesis of Aromatic Compounds 5 3. Strategy I: The Order of Events 11 4. One-Group C--X Disconnections 15 5. Strategy II: Chemoselectivity 21 6. Two-Group C--X Disconnections 29 7. Strategy III: Reversal of Polarity, Cyclisations, Summary of Strategy 35 8. Amine Synthesis 41 9. Strategy IV: Protecting Groups 49 10. One-Group C--C Disconnections I: Alcohols 55 11. General Strategy A: Choosing a Disconnection 61 12. Strategy V: Stereoselectivity A 67 13. One-Group C--C Disconnections II: Carbonyl Compounds 75 14. Strategy VI: Regioselectivity 81 15. Alkene Synthesis 87 16. Strategy VII: Use of Acetylenes (Alkynes) 93 17. Two-Group C--C Disconnections I: Diels-Alder Reactions 99 18. Strategy VIII: Introduction to Carbonyl Condensations 105 19. Two-Group C--C Disconnections II: 1,3-Difunctionalised Compounds 111 20. Strategy IX: Control in Carbonyl Condensations 115 21. Two-Group C--C Disconnections III: 1,5-Difunctionalised Compounds Conjugate (Michael) Addition and Robinson Annelation 123 22. Strategy X: Aliphatic Nitro Compounds in Synthesis 129 23. Two-Group Disconnections IV: 1,2-Difunctionalised Compounds 133 24. Strategy XI: Radical Reactions in Synthesis 139 25. Two-Group Disconnections V: 1,4-Difunctionalised Compounds 147 26. Strategy XII: Reconnection 153 27. Two-Group C--C Disconnections VI: 1,6-diCarbonyl Compounds 159 28. General Strategy B: Strategy of Carbonyl Disconnections 165 29. Strategy XIII: Introduction to Ring Synthesis: Saturated Heterocycles 173 30. Three-Membered Rings 181 31. Strategy XIV: Rearrangements in Synthesis 189 32. Four-Membered Rings: Photochemistry in Synthesis 195 33. Strategy XV: The Use of Ketenes in Synthesis 201 34. Five-Membered Rings 207 35. Strategy XVI: Pericyclic Reactions in Synthesis: Special Methods for Five-Membered Rings 213 36. Six-Membered Rings 221 37. General Strategy C: Strategy of Ring Synthesis 227 38. Strategy XVII: Stereoselectivity B 235 39. Aromatic Heterocycles 245 40. General Strategy D: Advanced Strategy 255 Index 263
"The book provides an excellent and pragmatic panorama of the various aspects of disconnective strategies, whilst keeping in mind the importance of protective strategies." ( Reviews , December 2010)
"The book provides an excellent and pragmatic panorama of the various aspects of disconnective strategies, whilst keeping in mind the importance of protective strategies." (Reviews, December 2010)

Author
Paul Wyatt, Stuart Warren
Publisher
John Wiley and Sons Ltd
Year
2009
Edition
2nd
ISBN-10
0470712279
ISBN-13
9780470712276
Format
Hardcover
Imprint
Wiley-Blackwell
Subtitle
The Disconnection Approach
DEWEY
547.2
Birth
1949
Language
English
Media
Book
Publication Date
2009-11-27
Pages
272
Illustrations
Illustrations
Residence
Eugene, OR, US
Short Title
WORKBK FOR ORGANIC SYNTHESIS T
Audience
Professional and Scholarly
Edition Description
Revised
Place of Publication
Hoboken
Country of Publication
United States
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